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Being a synthetic cannabinoid, This can be the chemical compound that offers synthetic cannabis users the “cotton mouth” experience, a powerful style of high, together with other Unwanted effects. JWH 018 is commonly called “Spice.
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The medication is actually a phenylacetylindole and it goes about as an agonist at CB1 and CB2 receptors. It's got a partiality of ~11 nM at CB1 and ~33 nM at CB2.
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Compared with many of the older JWH sequence compounds, this compound doesn't have a naphthalene ring, rather occupying this place with a two′-methoxy-phenylacetyl team, building JWH-250 a consultant member of a different course of cannabinoid ligands.
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Other 2′-substituted analogues like the methyl, chloro and bromo compounds will also be active and to some degree much more powerful.